Technology
By addressing these key issues, the field of regenerative medicine can overcome significant hurdles and unlock its full potential in revolutionizing patient care and providing effective treatments for a wide range of medical conditions:
Challenges in Current Regenerative Medicine Approaches:
- Identifying an Appropriate and Abundant Cell Source
- Addressing Immunorejection and Tumorigenesis
- Overcoming the Need for Cell Culture
- Ensuring Quality Control and Managing High Costs
- Addressing the Challenges of Cell Transplantation
At Progenicyte, we are going to first develop a drug for “Acute Regression with Down Syndrome”
Today, more than 90% of the Down Syndrome (DS) population receive an Alzheimer's diagnosis in their lifetime.
1.While DS is not a rare disease, “Acute Regression with DS”, typically ages from 20s to 50s, is a rare disease so we will develop as an orphan drug
2.A rare disease= low cost and fast development = early exit!
3.DS is a human model of AD- Extra Amyloid Precursor Protein (APP) in Chromosome 21.
Achieving Success in Memory Impairment: A Remarkable Milestone!
Our pre-clinical studies have revealed a remarkable breakthrough: our technology has demonstrated the ability to significantly augment the population of stem cells and promote neurogenesis.
studies conducted on
5xFAD mice: Transgenic Alzheimer model mice
Groundbreaking Results: APC100 Demonstrates Significant Neurogenesis Improvement in Animal Study within Just 3 Days!
Empowering Stem Cell Proliferation: Our Drug, APC-100, Reveals Remarkable Results in Boosting Neural and Mesenchymal Stem Cell Activity
- Our cutting-edge compound, KS217, has demonstrated a remarkable capability to enhance the proliferation of both neural and mesenchymal stem cells. Through our rigorous studies, we observed a substantial increase in the number of proliferating cells following treatment with KS217.
- Excitingly, when KS217 is combined with phenserine, our drug (APC100) exhibited even more remarkable effects. The synergistic combination resulted in elevated levels of neural stem cells and enhanced neurogenesis. Moreover, these positive outcomes were accompanied by notable improvements in cognitive function.
These findings represent a significant leap forward in our quest to unlock the full potential of stem cells and promote neurogenesis. The promising results achieved through the combination of KS217 and phenserine (our drug APC-100) pave the way for future advancements in the treatment of neurodegenerative conditions.
We remain committed to further exploring the vast possibilities of KS217 and its potential impact on neuroregeneration and cognitive enhancement.
With these groundbreaking outcomes, we are hopeful that our research will lead to transformative therapies that address the needs of individuals affected by cognitive decline and neurodegenerative disorders.
Studies conducted on
5xFAD mice: Transgenic Alzheimer model mice
Our applications
Regenerative medicine from cells to drugs
At Progenicyte, we are harnessing the power of our groundbreaking innovative technology—a small molecular weight compound—to pave the way for bringing a significant increase in endogenous stem cells to the forefront of clinical applications.
- No cell preparation or stem cell transplant surgeries required
- Disease modifying treatment
- Works for any stage of the disease
- Possible use for the prevention
Orally Administered Drugs
Our pioneering technology offers a transformative approach in the treatment of neurodegenerative diseases. By utilizing orally administered drugs, we have successfully developed a method to activate and enhance the existing neural stem cells within the brain throughout an individual's lifespan.
- This breakthrough holds immense promise for addressing a wide range of neurodegenerative conditions, including Parkinson's disease, Alzheimer's disease, ALS, Huntington's disease, stroke, and cervical spine/spinal cord injuries. Furthermore, our innovative approach extends its potential to encompass mental disorders and developmental disorders, such as Down syndrome.
- With our cutting-edge technology, we aim to revolutionize the field of neurodegenerative disease treatment and provide new hope for individuals affected by these debilitating conditions. By targeting neural stem cells, we believe we can unlock the inherent regenerative potential of the brain and significantly improve the lives of patients worldwide.
Expanding the Potential: Topical Application of Our Technology for Diverse Applications
Expanding the Potential: Topical Application of Our Technology for Diverse Applications
In addition to its oral administration capabilities, our pioneering technology exhibits remarkable versatility when applied topically. By harnessing the power of specifically formulated drugs, we have unlocked a range of exciting applications that can address various concerns.
- Reversing Skin Aging: Our topically administered drugs have demonstrated the remarkable ability to reverse the effects of skin aging. By leveraging the regenerative potential of our technology, we can rejuvenate and revitalize the skin, promoting a more youthful and vibrant appearance.
- Promoting Hair Growth: Hair loss and thinning hair can be distressing for individuals. Through targeted topical treatments, our technology has proven effective in stimulating hair growth. By activating dormant hair follicles and nurturing their regrowth, we offer a promising solution for those seeking to enhance their hair density and overall scalp health.
- Regenerating the Cornea by Increasing Mesenchymal Stem Cells: The regenerative properties of our technology extend to ocular health as well. By topically administering our drugs, we can boost the population of mesenchymal stem cells, leading to the regeneration of the cornea. This breakthrough has the potential to provide a non-invasive solution for corneal disorders, improving vision and quality of life for individuals affected by these conditions.
With these remarkable applications, our technology represents a paradigm shift in addressing age-related concerns, hair loss, and ocular health. Through topically administered drugs, we strive to provide effective and accessible solutions that enhance well-being and rejuvenate various aspects of human health.
Progenicyte Therapeutics' Pipeline
We are dedicated to advancing the clinical development of a groundbreaking small molecule compound that holds immense potential for augmenting endogenous stem cells. This pioneering compound was initially conceived by the esteemed neuroscience expert, Dr. Kiminobu Sugaya, and his exceptional research team.